2026001
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#!/usr/bin/env python3
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"""
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classification.py — single-seed image-level vs patient-level comparison.
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This script OWNS the shared classification-runs cache
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(scripts/cache/classification_runs.json): a flat list of per-(model, seed,
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split) run dicts. It reads any runs it needs from the cache and writes back any
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it has to compute, so the cache is maintained here. figure4_6.py references the
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same file to draw the 20-seed boxplots.
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Usage:
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conda activate fundus_imaging
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python scripts/classification.py
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"""
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import os, sys, json
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sys.path.insert(0, os.path.dirname(os.path.dirname(os.path.dirname(
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os.path.abspath(__file__)))))
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from classes import PatientLeakageClassifier
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SCRIPT_DIR = os.path.dirname(os.path.abspath(__file__))
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ROOT = os.path.dirname(SCRIPT_DIR)
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MODELS = ["VGG16", "DenseNet121", "EfficientNetB1", "MobileNetV2", "ResNet50"]
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SEED = 20
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CACHE_PATH = os.path.join(SCRIPT_DIR, "cache", "classification_runs.json")
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# Load the run cache: keep the raw list (to append to) and an index (to look up).
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runs = []
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if os.path.exists(CACHE_PATH):
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with open(CACHE_PATH) as f:
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runs = json.load(f)
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index = {(r["model"], r["seed"], r["split_type"]): r for r in runs}
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clf = None # lazily created only if the cache is missing something
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def get_run(name, split):
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"""Return the cached run, else compute it and write it back to the cache."""
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global clf
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hit = index.get((name, SEED, split))
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if hit is not None:
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return hit
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if clf is None:
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clf = PatientLeakageClassifier(
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os.path.join(ROOT, "results", "simple_patient_manifest.csv"),
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os.path.join(ROOT, "features"), n_jobs=8)
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print(f" (cache miss for {name}/{split} — computing)")
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r = clf.run(name, SEED, split)
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runs.append(r)
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index[(name, SEED, split)] = r
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os.makedirs(os.path.dirname(CACHE_PATH), exist_ok=True)
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with open(CACHE_PATH, "w") as f:
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json.dump(runs, f, indent=2)
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return r
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print(f"{'='*60}")
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print(f"IMAGE-LEVEL vs PATIENT-LEVEL (seed={SEED})")
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print(f"{'='*60}")
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results = []
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for name in MODELS:
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print(f"\n {name} ...")
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img = get_run(name, "image")
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pat = get_run(name, "patient")
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results.append({"model": name,
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"image_cv": img["cv"], "image_test": img["test"],
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"patient_cv": pat["cv"], "patient_test": pat["test"],
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"drop": img["test"] - pat["test"]})
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print(f" Image: CV={img['cv']:.4f} Test={img['test']:.4f}")
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print(f" Patient: CV={pat['cv']:.4f} Test={pat['test']:.4f}")
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print(f" Drop: {img['test'] - pat['test']:.4f}")
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print(f"\n {'Model':<18s} {'Img-CV':>8s} {'Img-Test':>9s} "
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f"{'Pat-CV':>8s} {'Pat-Test':>9s} {'Drop':>7s}")
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print(f" {'-'*54}")
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for r in results:
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print(f" {r['model']:<18s} {r['image_cv']:>8.4f} {r['image_test']:>9.4f} "
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f"{r['patient_cv']:>8.4f} {r['patient_test']:>9.4f} {r['drop']:>7.4f}")
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with open(os.path.join(ROOT, "results", "classification_pca50.json"), "w") as f:
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json.dump(results, f, indent=2)
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print(f"\nDONE")
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#!/usr/bin/env python3
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"""classification_siamese.py — Run classification with siamese patient manifest."""
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import os, sys, json
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import numpy as np
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os.environ["OMP_NUM_THREADS"] = "1"
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os.environ["OPENBLAS_NUM_THREADS"] = "1"
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os.environ["MKL_NUM_THREADS"] = "1"
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sys.path.insert(0, os.path.dirname(os.path.dirname(os.path.dirname(
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os.path.abspath(__file__)))))
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from classes import PatientLeakageClassifier
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ROOT = os.path.dirname(os.path.dirname(os.path.dirname(
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os.path.abspath(__file__))))
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MANIFEST = os.path.join(ROOT, "results", "siamese_manifest.csv")
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FEATURES_DIR = os.path.join(ROOT, "features")
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RESULTS_DIR = os.path.join(ROOT, "results")
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SEED = 20
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MODELS = ["VGG16", "DenseNet121", "EfficientNetB1", "MobileNetV2", "ResNet50"]
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clf = PatientLeakageClassifier(MANIFEST, FEATURES_DIR, n_jobs=6)
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print("=" * 60)
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print("Siamese-based patient classification")
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print("=" * 60)
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results = []
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for model_name in MODELS:
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print(f"\n {model_name} ...", flush=True)
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img = clf.run(model_name, SEED, "image")
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pat = clf.run(model_name, SEED, "patient")
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drop = img["test"] - pat["test"]
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results.append({
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"model": model_name, "manifest": "siamese",
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"image_cv": img["cv"], "image_test": img["test"],
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"patient_cv": pat["cv"], "patient_test": pat["test"],
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"drop": drop,
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})
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print(f" Image: CV={img['cv']:.4f} Test={img['test']:.4f}")
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print(f" Patient: CV={pat['cv']:.4f} Test={pat['test']:.4f} "
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f"Drop={drop:.4f}")
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# Save
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out = os.path.join(RESULTS_DIR, "classification_siamese.json")
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with open(out, "w") as f:
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json.dump(results, f, indent=2)
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# Comparison table
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print(f"\n{'='*80}")
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print("COMPARISON — All three patient-clustering methods (seed=20)")
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print(f"{'='*80}")
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def safe_load(path):
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if os.path.exists(path):
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with open(path) as f: return {r["model"]: r for r in json.load(f)}
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return None
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pca50 = safe_load(os.path.join(RESULTS_DIR, "classification_pca50.json"))
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thumbnail = safe_load(os.path.join(RESULTS_DIR, "classification_thumbnail.json"))
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siamese = {r["model"]: r for r in results}
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print(f"\n{'Model':<18s} {'PCA50 Pat':>10s} {'Thumb Pat':>11s} {'Siam Pat':>10s} "
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f"{'PCA50 Drop':>11s} {'Thumb Drop':>11s} {'Siam Drop':>10s}")
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print("-" * 82)
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for m in MODELS:
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f_pat = f"{pca50[m]['patient_test']:>10.4f}" if pca50 else " N/A"
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t_pat = f"{thumbnail[m]['patient_test']:>11.4f}" if thumbnail else " N/A"
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f_drop = f"{pca50[m]['drop']:>11.4f}" if pca50 else " N/A"
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t_drop = f"{thumbnail[m]['drop']:>11.4f}" if thumbnail else " N/A"
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print(f"{m:<18s} {f_pat} {t_pat} "
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f"{siamese[m]['patient_test']:>10.4f} {f_drop} {t_drop} "
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f"{siamese[m]['drop']:>10.4f}")
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print(f"\nSaved → {out}")
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print("DONE")
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@@ -0,0 +1,173 @@
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#!/usr/bin/env python3
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"""
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classification_thumbnail.py — Run the classification pipeline using the
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manuscript's thumbnail-based K-means patient manifest.
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Saves results alongside the feature-based results for comparison.
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Usage:
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conda activate fundus_imaging
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python scripts/classification_thumbnail.py
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"""
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import os, sys, csv, json, re
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import numpy as np
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sys.path.insert(0, os.path.dirname(os.path.dirname(os.path.dirname(
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os.path.abspath(__file__)))))
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from classes import PatientIdentifier, PatientLeakageClassifier
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# ---------------------------------------------------------------------------
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# Config
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# ---------------------------------------------------------------------------
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ROOT = os.path.dirname(os.path.dirname(os.path.dirname(
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os.path.abspath(__file__))))
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DATASET_PATH = os.path.join(os.path.dirname(ROOT),
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"The IQ-OTHNCCD lung cancer dataset")
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FEATURES_DIR = os.path.join(ROOT, "features")
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RESULTS_DIR = os.path.join(ROOT, "results")
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SEED = 20
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MODELS = ["VGG16", "DenseNet121", "EfficientNetB1", "MobileNetV2", "ResNet50"]
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# Known patient counts per class
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PATIENT_COUNTS = {
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"Bengin cases": 15,
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"Malignant cases": 40,
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"Normal cases": 55,
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}
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# ---------------------------------------------------------------------------
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# Step 1: Build thumbnail-based patient manifest
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# ---------------------------------------------------------------------------
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print("=" * 60)
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print("Building thumbnail-based patient manifest")
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print("=" * 60)
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# Collect all image filenames and class labels (same order as feature extraction)
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image_paths, all_labels, all_fnames = [], [], []
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for class_name in sorted(os.listdir(DATASET_PATH)):
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class_path = os.path.join(DATASET_PATH, class_name)
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if not os.path.isdir(class_path):
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continue
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for file in sorted(os.listdir(class_path)):
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if file.lower().endswith((".png", ".jpg", ".jpeg")):
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image_paths.append(os.path.join(class_path, file))
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all_labels.append(class_name)
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all_fnames.append(file)
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print(f"Found {len(image_paths)} images across "
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f"{len(set(all_labels))} classes")
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# Run thumbnail K-means
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labels_arr = np.array(all_labels)
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fnames_arr = np.array(all_fnames)
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identifier = PatientIdentifier(
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patient_estimates=PATIENT_COUNTS, random_state=42)
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groups = identifier.identify_from_thumbnails(
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DATASET_PATH, fnames_arr, labels_arr)
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# Build manifest
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manifest = identifier.build_assignment_dict(groups, fnames_arr, labels_arr)
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# Save manifest
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manifest_path = os.path.join(RESULTS_DIR, "thumbnail_patient_manifest.csv")
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def f2n(fname):
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m = re.search(r"\((\d+)\)", fname)
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num = int(m.group(1)) if m else None
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for cls_key, prefix in [
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("Bengin cases", "B"), ("Malignant cases", "M"), ("Normal cases", "N"),
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]:
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if fname.startswith(cls_key.rstrip("s")):
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return f"{prefix}_{num:03d}" if num else fname
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return fname
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with open(manifest_path, "w", newline="") as f:
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writer = csv.writer(f)
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writer.writerow(["patient_id", "class", "n_images", "images"])
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for pid in sorted(manifest.keys()):
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imgs = manifest[pid]
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short_names = [f2n(img) for img in imgs]
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cls = pid.split("_")[0] # "benign_0" → "benign"
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cls = {"benign": "Benign", "malig": "Malignant",
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"normal": "Normal"}.get(cls, cls)
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writer.writerow([pid, cls, len(imgs), ";".join(short_names)])
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print(f"Manifest saved → {manifest_path}")
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print(f" {len(manifest)} estimated patients")
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# Per-class stats
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for cls in ["Bengin cases", "Malignant cases", "Normal cases"]:
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short_cls = {"Bengin cases": "benign", "Malignant cases": "malig",
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"Normal cases": "normal"}[cls]
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cls_patients = {k: v for k, v in manifest.items()
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if k.startswith(short_cls)}
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n_pat = len(cls_patients)
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n_img = sum(len(v) for v in cls_patients.values())
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print(f" {cls}: {n_pat} patients, {n_img} images")
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# ---------------------------------------------------------------------------
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# Step 2: Run classification with thumbnail manifest
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# ---------------------------------------------------------------------------
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print(f"\n{'=' * 60}")
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print("Running classification (thumbnail manifest, seed=20)")
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print("=" * 60)
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clf = PatientLeakageClassifier(manifest_path, FEATURES_DIR, n_jobs=6)
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results = []
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for model_name in MODELS:
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print(f"\n {model_name} ...", flush=True)
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img = clf.run(model_name, SEED, "image")
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pat = clf.run(model_name, SEED, "patient")
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results.append({
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"model": model_name,
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"manifest": "thumbnail",
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"image_cv": img["cv"],
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"image_test": img["test"],
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"patient_cv": pat["cv"],
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"patient_test": pat["test"],
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"drop": img["test"] - pat["test"],
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})
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print(f" Image: CV={img['cv']:.4f} Test={img['test']:.4f}")
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print(f" Patient: CV={pat['cv']:.4f} Test={pat['test']:.4f} "
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f"Drop={img['test'] - pat['test']:.4f}")
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# ---------------------------------------------------------------------------
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# Save results
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# ---------------------------------------------------------------------------
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out_path = os.path.join(RESULTS_DIR, "classification_thumbnail.json")
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with open(out_path, "w") as f:
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json.dump(results, f, indent=2)
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# Also load feature-based results for side-by-side comparison
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feat_path = os.path.join(RESULTS_DIR, "classification_results.json")
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if os.path.exists(feat_path):
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with open(feat_path) as f:
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feat_results = json.load(f)
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print(f"\n{'=' * 80}")
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print("COMPARISON: Feature-based (PCA-50) vs Thumbnail K-means")
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print(f"{'=' * 80}")
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print(f"{'Model':<18s} {'Feat Image':>11s} {'Thumb Image':>12s} "
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f"{'Feat Pat':>9s} {'Thumb Pat':>10s} {'Feat Drop':>10s} "
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f"{'Thumb Drop':>11s}")
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print("-" * 78)
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for tr, fr in zip(results, feat_results):
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assert tr["model"] == fr["model"]
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print(f"{tr['model']:<18s} {fr['image_test']:>11.4f} "
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f"{tr['image_test']:>12.4f} {fr['patient_test']:>9.4f} "
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f"{tr['patient_test']:>10.4f} {fr['drop']:>10.4f} "
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f"{tr['drop']:>11.4f}")
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print(f"\nSaved → {out_path}")
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print("DONE")
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